Chelsea vs Liverpool, AC Milan vs Inter Milan, Sevilla vs Real Madrid, and Lyon vs PSG are just a few of our picks for must-watch game this Saturday and Sunday.

What to watch on Saturday, September 21, 2019

Leicester vs Tottenham at 07:30 ET/11:30 GMT

Broadcast listings: Telemundo Deportes En Vivo, NBCSports.com, UNIVERSO NOW, NBCSN, NBC Sports App, UNIVERSO, SiriusXM FC in the USA; TalkSport Radio UK, BT Sport Live, BT Sport 1, BT Sport Ultimate, BBC Radio, BBC Radio 5 Live in the UK; DAZN in Canada; Optus Sport in Australia

Preview: Leicester and Tottenham and fifth and third in the league, with only goal difference separating these two sides. The Foxes have begun the season well and despite the 1-0 loss at Man United last round, Vardy and Co. will be a tough test for Spurs. The north London giants head into this game on the back of a disappointing Champions League tie which saw them throw away a 2-0 lead to draw 2-2 with Olympiakos. They cannot afford another slip-up.

Man City vs Watford at 10:00 ET/14:00 GMT

Broadcast listings: NBC Sports App, Telemundo Deportes En Vivo, NBCSN, SiriusXM FC, UNIVERSO, UNIVERSO NOW, NBCSports.com in the USA; BBC Radio Manchester, BBC Radio 5 Live in the UK; DAZN in Canada; Optus Sport in Australia

Preview: Last weekend Norwich pulled off the impossible and became the first newly-promoted side to beat Guardiola's Man City. After the 3-2 loss, Pep congratulated Liverpool for winning the title despite it being only Matchday 5, hinting that the advantage the Reds boast will be difficult to overturn.

The Citizens returned to winning ways this midweek, beating Shakhtar in the Champions League. Their focus shifts back to the Premier League, with their next opponent being Watford. Does another upset await the reigning champions? Tune in to find out.

AC Milan vs Inter Milan at 14:45 ET/18:45 GMT

Broadcast listings: ESPN+, Rai Italia America in the USA; Premier Sports 1, Premier Player HD in the UK; TLN, Rai Italia America, DAZN in Canada; Rai Italia Australia, Kayo Sports, beIN Sports Connect, beIN Sports 1 in Australia; DAZN in Italy

Preview: It's only Matchday 4 but fans of Serie A will be treated to the Milan Derby. Inter will lock horns with AC Milan on Saturday in what is a highly-anticipated encounter. The Nerazzurri currently top the standings with nine points out of nine, being the only club so far to boast a perfect record. Antonio Conte's men suffered a recent slip-up in Europe, drawing 1-1 with Slavia Praha in their Champions League opener but will look to bounce back in the Milan Derby. Don't miss this clash.

What to watch on Sunday, September 22, 2019

West Ham vs Man Utd at 09:00 ET/13:00 GMT

Broadcast listings: Telemundo, SiriusXM FC, NBCSports.com, NBC Sports App, NBCSN, Telemundo Deportes En Vivo in the USA; SKY GO Extra, BBC Radio 5 Live, Sky Sports Main Event, Sky Sports Premier League in the UK; DAZN in Canada; Optus Sport in Australia

Preview: After going three games without a win, Man United have now won back-to-back games. A 1-0 victory over Leicester was followed by another one-nil triumph, this time in the Europa League against Astana. Next is a trip to the Olympic Stadium where they will lock horns with West Ham. However, Solskjaer is dealing with injuries to Pogba, Martial, and Shaw while Daniel James is a doubt.

Solskjaer could be without four key players

Paul Pogba, Anthony Martial, Daniel James, Luke Shaw, Manchester United, English Premier

Arsenal vs Aston Villa at 11:30 ET/15:30 GMT

Broadcast listings: SiriusXM FC, NBC Sports Gold in the USA; DAZN in Canada; Optus Sport in Australia

Preview: A 3-0 over Frankfurt helped paper over the cracks that are Arsenal's midfield and defense. In their last league game, the Gunners threw away a 2-0 lead to draw 2-2 with bottom-placed Watford. The north London giants would have been level on points with second-placed Man City had they won but are now in seventh due to a poor goal difference. Next up is a home clash with Aston Villa and given their Emirates Stadium form Emery's men will be confident of beating Aston Villa.

Chelsea vs Liverpool at 11:30 ET/15:30 GMT

Broadcast listings: SiriusXM FC, Telemundo, NBCSports.com, NBC Sports App, Telemundo Deportes En Vivo, NBCSN in the USA; SKY GO Extra, BBC Radio 5 Live, Sky Sports Premier League, Sky Sports Main Event in the UK; DAZN in Canada; Optus Sport in Australia

Preview: This is the game to watch this weekend. In what will be a repeat of the UEFA Super Cup, Chelsea will lock horns with the almighty Liverpool. Since that impressive performance against Klopp's men, the Blues have shown tons of promise, with Tammy Abraham being in spectacular form, but the London giants still struggle to secure wins.

The Reds, on the other hand, boast a perfect record in England with five wins out of five. However, their recent trip to Napoli showed that the Champions League holders aren't invincible, losing 2-0 to the Italians. Van Dijk committed an unusual error leading to a goal with Salah and Mane both failed to find the back of the net. Will Chelsea fancy their odds of bringing down Liverpool or will it be another comfortable victory for Klopp's men? Don't miss this showdown.

Klopp aiming to improve Liverpool's away record vs the top six

Jurgen Klopp, Liverpool, Arsenal, Manchester City, Manchester United, Arsenal, Tottenham, English Premier League

Sevilla vs Real Madrid at 15:00 ET/19:00 GMT

Broadcast listings: beIN SPORTS CONNECT, Fanatiz USA, beIN SPORTS, beIN SPORTS en Español in the USA; Premier Player HD, Premier Sports 2 in the UK; beIN SPORTS CONNECT Canada, beIN SPORTS en Español, beIN Sports Canada in Canada; beIN Sports 1, Kayo Sports, beIN Sports Connect in Australia; Movistar Laliga, Partidazo in Movistar LaLiga, Mitele Plus, Movistar+ in Spain

Preview: Zidane just can't seem to catch a break. The 3-2 win over Levante in La Liga did little to help win over the critics as Real Madrid still conceded twice. Fast forward to Wednesday and things went from bad to worse, with Los Blancos losing 3-0 to a PSG side without Mbappe, Cavani, and Neymar.

The Frenchman has won less than half of the games he has managed since returning to Santiago Bernabeu and is yet to get things to click after his summer spending fee. Next up for them is a tricky clash with Sevilla and should they suffer a defeat once again, talks of Zizou's sacking will only pick up pace.

Zidane's second spell with Real Madrid isn't going great

Zinedine Zidane, Real Madrid, La Liga, UEFA Champions League

Lyon vs PSG at 15:00 ET/19:00 GMT

Broadcast listings: beIN SPORTS CONNECT, Fanatiz USA in the USA; BT Sport Live, BT Sport 1, BT Sport Ultimate in the UK; beIN SPORTS CONNECT Canada in Canada; beIN SPORTS 3, beIN Sports Connect, Kayo Sports in Australia; Canal+ France in France

Preview: Fresh off their 3-0 win over Real Madrid in the Champions League, PSG will look to beat rivals Lyon in Ligue 1. The French champions will welcome back Neymar, who was suspended for the Champions League opener. The Brazilian was heavily booed last weekend but scored the winning goal to silence his critics and will be aiming to pull off the remarkable once more.